ABSTRACT
Objective To investigate the effect of atorvastatin calcium on serum endothelin-1(ET-1), polyamine oxidase(PAO), heart-type fatty acid binding protein(H-FABP), vascular endothelial growth factor(VEGF), 100β, inflammatory cytokines and nerve function in patients with acute cerebral infarction.Methods According to the random number table, 113 patients were randomly divided into two groups (n=61) and control group (n=52).The control group received conventional treatment methods, and observation group received atorvastatin calcium on the basis of control group. The treatment course was two weeks.Serum ET-1, PAO, H-FABP, VEGF, S100β, inflammatory cytokines and NIHSS score were compared between two groups before treatment, 7d and 14d after treatment.Results The serum levels of ET-1, PAO, H-FABP after 7d, 14d treatment of observation group was significantly lower than that of control group, respectively (P<0.05).The VEGF level of observation group after 7 d, 14 d treatment of observation group was significantly higher than that of control group, respectively (P<0.05).The S100βlevel after 7 d, 14 d treatment of observation group was significantly lower than that of control group, respectively (P<0.05).The hs-CRP, IL-8, TNF-αlevels after 7 d, 14 d treatment of observation group was significantly lower than that of control group, respectively (P<0.05).NIHSS score after treatment of observation group was significantly lower than that of control group (P<0.05).Conclusion The atorvastatin calcium can improve neurological function in patients with brain injury through reducing serum ET-1, PAO, H-FABP and S100βlevels, promote angiogenesis through increasing VEGF expression, and alleviate inflammation and ischemia-reperfusion injury through reducing inflammatory cytokines, thereby promote neurological functional recovery.
ABSTRACT
OBJECTIVE@#To estimate the predictable value of histopathologic parameters in chronic rhinosinusitis with nasal polyps (CRSwNP) after endoscopic sinus surgery(ESS).@*METHOD@#Symptomatology was rated in 53 patients 12 to 24 months after ESS. Specimens taken during the surgical procedure were examined and scored for eosinophils, goblet cells, lymphocytes, subepithelial thickening, subepithelial edema and submucous gland formation. The correlation between histopathologic parameters and postoperative symptoms was then evaluated.@*RESULT@#The most common symptome after ESS were nasal obsruction, nasal secretion, discharge and sneezing. The correlation between goblet cells and sneezing, discharge, submucous gland formation and headache, subepithelial edema and postnasal secretion was significant (P < 0.05).@*CONCLUSION@#Certain histopathologic parameters in CRSwNP are predictive of favorable response to ESS.
Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , Chronic Disease , Endoscopy , Nasal Polyps , Diagnosis , Pathology , General Surgery , Postoperative Period , Predictive Value of Tests , Sinusitis , Diagnosis , Pathology , General Surgery , Surveys and Questionnaires , Treatment OutcomeABSTRACT
Objecive:To estimate the predictable value of histopathologic parameters in chronic rhinosinusitis with nasal polyps(CRSwNP)after endoscopic sinus surgery(ESS). Method:Symptomatology was rated in 53 patients 12 to 24 months after ESS.Specimens taken during the surgical procedure were examined and scored for eosinophils.goblet cells,lymphocytes,subepithelial thickening,subepithelial edema and submucous gland formation. The correlation between histopathologic parameters and postoperative symptoms was then evaluated. Result:The most common symptome after ESS were nasal obsruction,nasal secretion,discharge and sneezing. The correlation between goblet cells and sneezing,discharge,submueous gland formation and headache,subepithelial edema and postnasal secretion was significant(P＜0.05). Conclusion:Certain histopathologic parameters in CRSwNP are predictive of favorable response to ESS.